Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Dosing

The dose of selegiline will be different for different patients. Your doctor will determine the proper dose of selegiline for you. Follow your doctor's orders or the directions on the label.

For the treatment of Parkinson's disease, the usual dose of selegiline is 5 mg two times a day, taken with breakfast and lunch. Some patients may need less than this.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if you do not remember the missed dose until late afternoon or evening, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For selegiline, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to selegiline. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy Selegiline has not been studied in pregnant women. However, this medicine has not been shown to cause birth defects or other problems in animal studies.

Breast-feeding It is not known whether selegiline passes into the breast milk.

Children Studies on this medicine have been done only in adult patients and there is no specific information about its use in children. Therefore, be sure to discuss with your doctor the use of this medicine in children.

Older adults In studies done to date that included elderly people, selegiline did not cause different side effects or problems in older people than it did in younger adults.

Other medicines Although certain medicines should not be used together at all, in other cases 2 different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking selegiline, it is especially important that your health care professional know if you are taking any of the following:

• Antidepressants, tricyclic (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Norpramin], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Pamelor], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil]) or
• Fluoxetine (e.g., Prozac) or
• Fluvoxamine (e.g., Luvox) or
• Meperidine (e.g., Demerol) or
• Nefazodone (e.g., Serzone) or
• Paroxetine (e.g., Paxil) or
• Sertraline (e.g., Zoloft) or
• Venlafaxine (e.g., Effexor) Using these medicines together may increase the chance of serious side effects

• Stomach ulcer (history of) Selegiline may make the condition worse