Dosing

The dose of orphenadrine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of orphenadrine. If your dose is different, do not change it unless your doctor tells you to do so.

• For extended-release tablet dosage form:
  • For relaxing stiff, sore muscles:
    • Adults and teenagers 100 milligrams (mg) two times a day, in the morning and evening.
    • Children Use and dose must be determined by your doctor.
• For oral tablet dosage form:
  • For relaxing stiff, sore muscles and for Parkinson's disease:
    • Adults 50 mg three times a day.
    • Children Dose must be determined by your doctor.
• For injection dosage form:
  • For relaxing stiff, sore muscles:
    • Adults 60 mg, injected into a muscle or a vein, every twelve hours as needed.
    • Children Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of this medicine and remember within an hour or so of the missed dose, take it right away. But if you do not remember until later, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For orphenadrine, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to orphenadrine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy Orphenadrine has not been reported to cause birth defects or other problems in humans.

Breast-feeding It is not known whether orphenadrine passes into the breast milk. However, orphenadrine has not been reported to cause problems in nursing babies.

Children Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of orphenadrine in children with use in other age groups.

Older adults Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information about the use of orphenadrine in the elderly.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking orphenadrine, it is especially important that your health care professional knows if you are taking any of the following:

• Alcohol or
• Central nervous system (CNS) depressants or
• Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil]) The chance of side effects may be increased

• Disease of the digestive tract, especially esophagus disease, stomach ulcer, or intestinal blockage, or
• Enlarged prostate or
• Fast or irregular heartbeat or
• Glaucoma or
• Myasthenia gravis or
• Urinary tract blockage Orphenadrine has side effects that may be harmful to people with these conditions

• Heart disease or
• Kidney disease or
• Liver disease The chance of side effects may be increased