Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may lead to other medical problems because of an overdose.

Dosing

The dose of nabilone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of nabilone. If your dose is different, do not change it unless your doctor tells you to do so.

• For oral dosage forms (capsules):
  • For nausea and vomiting caused by cancer medicines:
    • Adults and teenagers Usually 1 or 2 milligrams (mg) twice a day. Your doctor will tell you how and when to take this medicine while you are taking your cancer medicine.
    • Children Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nabilone, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to nabilone or marijuana products. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy Studies have not been done in pregnant women. However, studies in animals have shown a decrease in successful pregnancies and a decrease in the number of live babies born, when nabilone was given in doses many times the usual human dose.

Breast-feeding It is not known whether nabilone passes into the breast milk. However, nabilone is not recommended during breast-feeding because other medicines similar to nabilone that pass into the breast milk have been shown to cause unwanted effects in the nursing baby.

Children Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of nabilone in children with use in other age groups.

Older adults Fast or pounding heartbeat, feeling faint or lightheaded, and unusual tiredness or weakness may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of nabilone. Also, the effects this medicine may have on the mind may be of special concern in the elderly. Therefore, older people should be watched closely while taking this medicine.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking nabilone, it is especially important that your health care professional know if you are taking any of the following:

• Central nervous system (CNS) depressants (medicine that causes drowsiness) or
• Tricyclic antidepressants (medicine for depression) Taking these medicines with nabilone may increase the CNS-depressant effects

• Alcohol abuse (or history of) or
• Drug abuse or dependence (or history of) Dependence on nabilone may develop

• Emotional problems or
• Heart disease or
• Low blood pressure or
• Manic or depressive states or
• Mental illness (severe) or
• Schizophrenia Nabilone may make the condition worse

• Liver disease (severe) Higher blood levels of nabilone may occur, increasing the chance of side effects