This medicine is used to relieve or prevent the symptoms of motion sickness or vertigo (dizziness caused by other medical problems). Take it only as directed. Do not take more of it or take it more often than stated on the label or ordered by your doctor. To do so may increase the chance of side effects.

Dosing

The dose of buclizine, cyclizine, or meclizine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of buclizine, cyclizine, or meclizine. If your dose is different, do not change it unless your doctor tells you to do so.

For buclizine
• For oral dosage form (chewable tablets):
  • To prevent motion sickness:
    • Adults and teenagers The usual dose is 50 milligrams (mg) thirty minutes before travel. The dose may be repeated every four to six hours if needed. Not more than 150 mg should be taken in one day.
    • Children Dose must be determined by your doctor.

For cyclizine
• For oral dosage form (tablets):
  • To prevent and treat motion sickness:
    • Adults and teenagers The usual dose is 50 milligrams (mg) thirty minutes before travel. The dose may be repeated every four to six hours if needed. Not more than 200 mg should be taken in one day.
    • Children 6 to 12 years of age The usual dose is 25 mg thirty minutes before travel. The dose may be repeated every six to eight hours if needed. Not more than 75 mg should be taken in one day.
    • Children up to 6 years of age Use and dose must be determined by your doctor.
• For injection dosage form:
  • To prevent and treat motion sickness:
    • Adults and teenagers The usual dose is 50 mg injected into a muscle every four to six hours as needed.
    • Children Dose is based on body weight and must be determined by your doctor. The usual dose is 1 mg per kilogram (0.45 mg per pound) of body weight injected into a muscle three times a day as needed.

For meclizine
• For oral dosage forms (tablets and chewable tablets):
  • To prevent and treat motion sickness:
    • Adults and children 12 years of age or older The usual dose is 25 to 50 milligrams (mg) one hour before travel. The dose may be repeated every twenty-four hours as needed.
    • Children up to 12 years of age Use and dose must be determined by your doctor.
  • To prevent and treat vertigo (dizziness):
    • Adults and children 12 years of age or older The usual dose is 25 to 100 mg a day as needed, divided into smaller doses.
    • Children up to 12 years of age Use and dose must be determined by your doctor.

Missed dose

If you must take this medicine regularly and you miss a dose, take the missed dose as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store the tablets in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

If you are taking this medicine without a prescription, carefully read and follow any precautions on the label. For buclizine, cyclizine, and meclizine, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to buclizine, cyclizine, or meclizine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy These medicines have not been shown to cause birth defects or other problems in humans. However, studies in animals have shown that buclizine, cyclizine, and meclizine given in doses many times the usual human dose cause birth defects, such as cleft palate.

Breast-feeding Although these medicines may pass into breast milk, they have not been reported to cause problems in nursing babies. However, since these medicines tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some patients.

Children There is no specific information comparing use of buclizine, cyclizine, and meclizine in children with use in other age groups. However, children may be especially sensitive to the anticholinergic effects (e.g., dryness of mouth, nose, and throat) of these medicines.

Older adults There is no specific information comparing use of buclizine, cyclizine, and meclizine in the elderly with use in other age groups. Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. However, older people may be especially sensitive to the anticholinergic effects (e.g., constipation; difficult urination; dryness of mouth, nose, and throat) of these medicines.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking buclizine, cyclizine, or meclizine, it is especially important that your health care professional know if you are taking the following:

• Central nervous system (CNS) depressants, other (medicines that make you drowsy or less alert) or
• Tricyclic antidepressants (medicine for depression) Use with buclizine, cyclizine, or meclizine may increase the side effects of either medicine

• Asthma, bronchitis, emphysema, or other chronic lung disease Cyclizine or meclizine may cause serious breathing problems in patients who have any of these conditions

• Enlarged prostate or
• Glaucoma or
• Intestinal blockage or
• Urinary tract blockage Buclizine, cyclizine, or meclizine may make these conditions worse

• Heart failure Cyclizine may make the condition worse