For patients taking this medicine by mouth:

• If you are taking the capsule, tablet, liquid, or extended-release (not including the once-a-day capsule or tablet) form of this medicine, it works best when taken with a glass of water on an empty stomach (either 30 minutes to 1 hour before meals or 2 hours after meals). In some cases your doctor may want you to take this medicine with meals or right after meals to lessen stomach upset. If you have any questions about how you should be taking this medicine, check with your doctor.
• If you are taking the once-a-day capsule or tablet form of this medicine, some products are to be taken each morning after fasting overnight and at least 1 hour before eating. However, other products are to be taken in the morning or evening with or without food. Be sure you understand exactly how to take the medicine prescribed for you. Try to take the medicine about the same time each day.
• There are several different forms of aminophylline, oxtriphylline, and theophylline capsules and tablets. If you are taking:
  • Enteric-coated or delayed-release tablets, swallow the tablets whole. Do not crush, break, or chew before swallowing.
  • Extended-release capsules, swallow the capsule whole. Do not crush, break, or chew before swallowing. Do not open the capsule and sprinkle the beads onto food unless told to do so by your health care professional.
  • Extended-release tablets, swallow the tablets whole. Do not break (unless tablet is scored for breaking), crush, or chew before swallowing.

Use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chance of serious side effects.

In order for this medicine to help your medical problem, it must be taken every day in regularly spaced doses as ordered by your doctor . This is necessary to keep a constant amount of this medicine in the blood. To help keep the amount constant, do not miss any doses.

Dosing

When you are taking aminophylline, oxtriphylline, or theophylline, it is very important that you get the exact amount of medicine that you need. The dose of these medicines will be different for different patients. Your doctor will determine the proper dose of these medicines for you. Follow your doctor's orders or the directions on the label.

After you begin taking aminophylline, oxtriphylline, or theophylline, it is very important that your doctor check the level of medicine in your blood at regular intervals to find out if your dose needs to be changed. Do not change your dose of aminophylline, oxtriphylline, or theophylline unless your doctor tells you to do so.

The number of capsules or tablets or teaspoonfuls of solution or syrup that you take depends on the strength of the medicine. Also, the number of doses you take each day and the time between doses depend on whether you are taking a short-acting or long-acting form of aminophylline, oxtriphylline, or theophylline.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store the capsule or tablet form of this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Keep the liquid form of this medicine from freezing.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aminophylline, oxtriphylline, or theophylline, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to aminophylline, ethylenediamine (contained in aminophylline), oxtriphylline, or theophylline.

Diet Make certain your health care professional knows if you are on any special diet, such as a high-protein, low-carbohydrate or a low-protein, high-carbohydrate diet.

Pregnancy Aminophylline, oxtriphylline, and theophylline are frequently used to treat asthma in pregnant women. Although there are no studies on birth defects in humans, problems have not been reported. Some studies in animals have shown that aminophylline, oxtriphylline, and theophylline can cause birth defects when given in doses many times the human dose.

Because your ability to clear theophylline from your body may decrease later in pregnancy, your doctor may want to take blood samples during your pregnancy to measure the amount of medicine in the blood. This will help your doctor decide whether the dose of this medicine should be changed.

Theophylline crosses the placenta. Use of aminophylline, oxtriphylline, or theophylline during pregnancy may cause unwanted effects such as fast heartbeat, irritability, jitteriness, or vomiting in the newborn infant if the amount of medicine in your blood is too high.

Breast-feeding Theophylline passes into the breast milk and may cause irritability in nursing babies of mothers taking aminophylline, oxtriphylline, or theophylline.

Children Very young children and newborn infants require a lower dose than older children. If the amount of theophylline in the blood is too high, side effects are more likely to occur. Your doctor may want to take blood samples to determine whether a dose change is needed.

Older adults Patients older than 60 years of age are likely to require a lower dose than younger adults. If the amount of theophylline is too high, side effects are more likely to occur. Your doctor may want to take blood samples to determine whether a dose change is needed.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking aminophylline, oxtriphylline, or theophylline, it is especially important that your health care professional know if you are taking any of the following:

• Beta-adrenergic blocking agents including those used in the eyes (acebutolol [e.g., Sectral], atenolol [e.g., Tenormin], betaxolol [e.g., Betoptic, Kerlone], bisoprolol [e.g., Zebeta], carteolol [e.g., Cartrol], labetalol [e.g., Normodyne], levobunolol [e.g., Betagan], metipranolol [e.g., OptiPranolol], metoprolol [e.g., Lopressor], nadolol [e.g., Corgard], oxprenolol [e.g., Trasicor], penbutolol [e.g., Levatol], pindolol [e.g., Visken], propranolol [e.g., Inderal], sotalol [e.g., Sotacor], timolol [e.g., Blocadren, Timoptic]) These medicines may prevent aminophylline, oxtriphylline, or theophylline from working properly

• Cimetidine (e.g., Tagamet) or
• Ciprofloxacin (e.g., Cipro) or
• Clarithromycin (e.g., Biaxin) or
• Enoxacin (e.g., Penetrex) or
• Erythromycin (e.g., E-Mycin) or
• Fluvoxamine (e.g., Luvox) or
• Mexiletine (e.g., Mexitil) or
• Pentoxifylline (e.g., Trental) or
• Propranolol (e.g., Inderal) or
• Tacrine (e.g., Cognex) or
• Thiabendazole or
• Ticlopidine (e.g., Ticlid) or
• Troleandomycin (e.g., TAO) These medicines may increase the effects of aminophylline, oxtriphylline, or theophylline

• Moricizine (e.g., Ethmozine) or
• Phenytoin (e.g., Dilantin) or
• Rifampin (e.g., Rifadin) These medicines may decrease the effects of aminophylline, oxtriphylline, or theophylline

• Smoking tobacco or marijuana Starting or stopping smoking may change the effectiveness of these medicines

• Convulsions (seizures) Aminophylline, oxtriphylline, or theophylline may make this condition worse

• Heart failure or
• Liver disease or
• Underactive thyroid The effects of aminophylline, oxtriphylline, or theophylline may be increased